Methylcobalamin 10 mg

Appearance: Our Injectable Methylcobalamin comes as a lyophilized (freeze-dried) red powder, reconstituted into a red injectable solution.

Size: 10 mL vial

Strength: 1 mg/mL (after reconstitution)

Route: Intramuscular, Subcutaneous, Intravenous Infusion when mixed in a large-volume parenteral solution.

Mixing Concentration: Mix with 10 mL diluent to yield a 1 mg/mL concentration. (1:1)

Recommended Dosing: 1mg Weekly

Prescribing Example: Mix with 10 mL diluent and inject 1ml (100 units on syringe ) subcutaneously once a week.

Mix with 10 mL diluent and inject 1ml on syringe Intramuscularly once a week.

• * 10 mL Mixing Syringe Prescription Required

Methylcobalamin injection is generally well tolerated.
Common reactions include:
Local injection site pain or erythema
Headache or dizziness
Transient flushing
Rare: Anaphylaxis or hypersensitivity

2. Causes and Consequences of Impaired Methionine Synthase Activity in Acquired and Inherited Disorders of Vitamin B Metabolism. Critical Reviews in Biochemistry and Molecular Biology. 2022. Guéant JL, Guéant-Rodriguez RM, Kosgei VJ, Coelho D.
3. Vitamin B , Folate, and the Methionine Remethylation Cycle-Biochemistry, Pathways, and Regulation.Journal of Inherited Metabolic Disease. 2019. Froese DS, Fowler B, Baumgartner MR.
4. Human B-Dependent Enzymes: Methionine Synthase and Methylmalonyl-CoA Mutase. Methods in Enzymology. 2022. Mascarenhas R, Gouda H, Ruetz M, Banerjee R.
5. Biochemistry of B12-Cofactors in Human Metabolism. Sub-Cellular Biochemistry. 2011. Kräutler B.
6. Molecular and Cellular Effects of Vitamin B12 in Brain, Myocardium and Liver Through Its Role as Co-Factor of Methionine Synthase. Biochimie. 2013. Guéant JL, Caillerez-Fofou M, Battaglia-Hsu S, et al.
7. Cobalamin Coenzyme Forms Are Not Likely to Be Superior to Cyano- And Hydroxyl-Cobalamin in Prevention or Treatment of Cobalamin Deficiency. Molecular Nutrition & Food Research. 2015. Obeid R, Fedosov SN, Nexo E.
8. Treatment of Vitamin B12 Deficiency-Methylcobalamine? Cyancobalamine? Hydroxocobalamin?-Clearing the Confusion. European Journal of Clinical Nutrition. 2014. Thakkar K, Billa G.
9. Using Corneal Confocal Microscopy to Compare Mecobalamin Intramuscular Injections vs Oral Tablets in Treating Diabetic Peripheral Neuropathy: A RCT. Scientific Reports. 2021. Zhang Y, Fan D, Zhang Y, et al.
10. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021. Didangelos T, Karlafti E, Kotzakioulafi E, et al.
11. Efficacy and Safety of Mecobalamin on Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Alternative and Complementary Medicine. 2020. Sawangjit R, Thongphui S, Chaichompu W, Phumart P.
12. Efficacy of B Vitamin Supplementation on Global Cognitive Function in Older Adults: A Systematic Review and Meta-Analysis. Nutrition Reviews. 2025. Berg J, Grant R, Siervo M, Stephan BCM, Tully PJ.New
13. B Vitamins and Prevention of Cognitive Decline and Incident Dementia: A Systematic Review and Meta-Analysis. Nutrition Reviews. 2022. Wang Z, Zhu W, Xing Y, Jia J, Tang Y.
14. Vitamin and Mineral Supplementation for Preventing Dementia or Delaying Cognitive Decline in People With Mild Cognitive Impairment. The Cochrane Database of Systematic Reviews. 2018. McCleery J, Abraham RP, Denton DA, et al.
15. Influences of Vitamin B Supplementation on Cognition and Homocysteine in Patients With Vitamin B Deficiency and Cognitive Impairment. Nutrients. 2022. Ueno A, Hamano T, Enomoto S, et al.
16. A Systematic Review of Nutraceutical Interventions for Mitochondrial Dysfunctions in Myalgic Encephalomyelitis/­Chronic Fatigue Syndrome. Journal of Translational Medicine. 2021. Maksoud R, Balinas C, Holden S, et al.
17. Vitamin and Mineral Status in Chronic Fatigue Syndrome and Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis. PloS One. 2016. Joustra ML, Minovic I, Janssens KAM, Bakker SJL, Rosmalen JGM.
18. Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia. PloS One. 2015. Regland B, Forsmark S, Halaouate L, et al.
19. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/­Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Frontiers in Pharmacology. 2019. van Campen CLM, Riepma K, Visser FC.
20. A Clinician’s Guide for Trending Cardiovascular Nutrition Controversies: Part II. Journal of the American College of Cardiology. 2018. Freeman AM, Morris PB, Aspry K, et al.
21. Dosage Exploration of Combined B-Vitamin Supplementation in Stroke Prevention: A Meta-Analysis and Systematic Review. The American Journal of Clinical Nutrition. 2024. Zhang N, Wu Z, Bai X, et al.
22. Problem in the Recent American Heart Association Guideline on Secondary Stroke Prevention: B Vitamins to Lower Homocysteine Do Prevent Stroke. Stroke. 2022. Spence JD, Hankey GJ.
23. B Vitamins in Stroke Prevention: Time to Reconsider. The Lancet. Neurology. 2017. Spence JD, Yi Q, Hankey GJ.
24. The Tissue Profile of Metabolically Active Coenzyme Forms of Vitamin B12 Differs in Vitamin B12-Depleted Rats Treated With Hydroxo-B12 or Cyano-B12. The British Journal of Nutrition. 2018. Greibe E, Kornerup LS, Juul CB, et al.
25. A Brief Overview of the Diagnosis and Treatment of Cobalamin (B12) Deficiency. Food and Nutrition Bulletin. 2024. Wolffenbuttel BHR, McCaddon A, Ahmadi KR, Green R.
26. A Review of Vitamin B12 in Dermatology. American Journal of Clinical Dermatology. 2015. Brescoll J, Daveluy S.
27. Vitamin B12 Deficiency. The New England Journal of Medicine. 2013. Stabler SP.
28. Association Between Acid-Lowering Agents, Metformin, and Vitamin B12 Among Boston-Area Puerto Ricans. The Journal of Nutrition. 2023. Dinesh D, Lee JS, Scott TM, Tucker KL, Palacios N.
29. Vitamin B12 Deficiency: Common Questions and Answers. American Family Physician. 2025. Patel H, McGuirk R.
30. Drug-Induced Megaloblastic Anemia. The New England Journal of Medicine. 2015. Hesdorffer CS, Longo DL.
31. Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications. Advances in Nutrition. 2018. Miller JW.
32. Metformin-Induced Vitamin B12 Deficiency Can Cause or Worsen Distal Symmetrical, Autonomic and Cardiac Neuropathy in the Patient With Diabetes. Diabetes, Obesity & Metabolism. 2022. Bell DSH.
33. Vitamin B12 Supplementation During Pregnancy for Maternal and Child Health Outcomes. The Cochrane Database of Systematic Reviews. 2024. Finkelstein JL, Fothergill A, Venkatramanan S, et al.
34. Vitamin B-12 Supplementation During Pregnancy and Early Lactation Increases Maternal, Breast Milk, and Infant Measures of Vitamin B-12 Status. The Journal of Nutrition. 2014. Duggan C, Srinivasan K, Thomas T, et al.

34. The Effect of Vitamin B12 Supplementation During Pregnancy on Infant Growth and Development in Nepal: A Community-Based, Double-Blind, Randomized, Placebo-Controlled Trial. Lancet. 2023. Chandyo RK, Kvestad I, Ulak M, et al.